The human major histocompatibility complex HLA is located on the short arm of chromosome 6. It is known to be the most polymorphic genetic system in humans. The biological role of the HLA class I and class II molecules is to present processed peptide antigens. The HLA system is clinically important as transplantation antigens. Molecular HLA allele typing is routinely performed to provide HLA class I and class II allele matching in unrelated donor hematopoietic stem cell transplantation. Prospective lymphocyte crossmatching is critical in solid organ transplantation to prevent allograft rejection.
The HLA system has been well known as transplantation antigens, but the primary biological role of HLA molecules is in the regulation of immune response. Clinical HLA laboratories perform various tests to support the transplant programs; including HLA typing of the recipient and the potential donor, screening and identification of HLA antibodies in the recipient, and detection of antibodies in the recipient that are reactive with lymphocytes of a prospective donor (i.e., crossmatching).
Treatment that uses your body’s own immune system to help fight cancer
Transplant rejection can be reduced through serotyping to determine the most appropriate donor-recipient match
The onset of the adverse reaction may be sudden or develop over time
A medical condition in which your immune system mistakenly attacks your own body
“The most important function of HLA molecule is in the induction and regulation of immune responses.”
HLA genes are highly polymorphic, and the number of known alleles continues to grow. Accurately identifying which alleles are present in an individual is important in many areas, such as drug safety, disease susceptibility, neoantigen prediction for cancer treatment, regenerative medicine, and organ transplantation.
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